Voraxaze® (Glucarpidase) for Toxic Plasma Methotrexate Concentrations
Toxic Plasma Methotrexate Concentrations
Methotrexate is an antifolate drug. It is used for treatment of cancer, ectopic pregnancies, induction of medical abortion, and autoimmune diseases. Methotrexate was developed and is still being used for chemotherapy and effective in treating various cancers including breast cancer, lymphoma, leukemia, among others.
Methotrexate is widely used as an anti-cancer agent and high-dose methotrexate is administered for the treatment of various childhood and adult cancers. High-dose methotrexate has been essential in the treatment of lymphomas and leukemia and can be given to patients with normal kidney functions. However, it is necessary to recognize and treat methotrexate-induced renal dysfunction to avoid reaching toxic levels that are potentially life-threatening.
Glucarpidase for Toxic Plasma Methotrexate Concentrations
Toxic Plasma Methotrexate Concentrations in the body can be combated using the US FDA-approved Glucarpidase. Glucarpidase, generic name of Voraxaze® is used as an injection as part of the therapy to patients with failed methotrexate clearance. Mostly due to kidney malfunction.
Indications and Usage
If a patient has impaired renal function which leads to patients with delayed methotrexate clearance, and the plasma methotrexate is in toxic concentration levels, Voraxaze® (Glucarpidase) is administered to them and indicated for its treatment.
Voraxaze® (Glucarpidase) is an FDA-approved IV drug used for the treatment of elevated methotrexate levels which is defined greater than 1 micromole per liter. Voraxaze® (Glucarpidase) basically converts methotrexate to inactive metabolites. These metabolites DAMPA and glutamate are metabolized by the liver thus providing another route to eliminate methotrexate to renal clearance during high-dose methotrexate treatment.
Dosage and Administration
Voraxaze® (Glucarpidase) should be administered as a single IV injection of 50 units per kilogram. Voraxaze® (Glucarpidase) is administered as a bolus injection intravenously over five minutes. IV line should be flushed before and after the administration of Voraxaze® (Glucarpidase).
Where to purchase Voraxaze® (Glucarpidase)
Voraxaze® (Glucarpidase) is sold locally and online. Remember that when buying Voraxaze® (Glucarpidase) online, choose only from reliable online drugstores like CancerDrugs.supply.
At CancerDrugs.supply, you can make sure that the drugs are only from reliable genuine suppliers.
Frequently Asked Questions
“What are the common side effects that I may experience?”
Some common side effects are headache, hypotension or having low blood pressure, paresthesia or the tingling sensations on the skin, flushing, nausea and/or vomiting.
Glucarpidase should not be taken with leucovorin or given simultaneously with the latter. Leucovorin is an alternative substrate and thus may fight with methotrexate for the enzyme. Moreover, leucovorin is made inert by Glucarpidase.
“Is Voraxaze® (Glucarpidase) safe for pregnant women?”
Well-controlled studies related to the effect of Voraxaze® (Glucarpidase) in pregnant women are not adequate therefore it is not truly known as to whether it can cause harm to the fetus when administered. So as much as possible, administer Voraxaze® (Glucarpidase) only when clearly needed by the pregnant woman.
“Is Voraxaze® (Glucarpidase) safe for nursing mothers?”
There are no adequate studies to prove if Voraxaze® (Glucarpidase) is released in human milk. But since a lot of drugs are released in human milk, it is important to take caution when administering Voraxaze® (Glucarpidase) to breastfeeding women.
“Is it possible to overdose in Voraxaze® (Glucarpidase)?”
There are no reported cases of people overdosing in Voraxaze® (Glucarpidase).
My father was diagnosed with lymphoma and he was administered with methotrexate. Unfortunately, because of a previous medical history, he contracted kidney malfunction while under high-dose methotrexate treatment. He was given Voraxaze® (Glucarpidase) in order to address the toxic levels of methotrexate in his body. So far, he is doing better except for the occasional vomiting and paresthesia. Lena.
I had to undergo Glucarpidase treatment since the clearance of the methotrexate levels in my body failed because of renal dysfunction. My doctor observed lower methotrexate levels and were directly inactivated due upon the administration of Glucarpidase. I am just happy and hoping to the continuation of the bettering of my health.Ben, Ohio
I had paresthesia while under Voraxaze® (Glucarpidase) treatment. It was really bothersome but of course, one cannot complain too much. I had impaired kidney function that is why to combat the toxic concentration levels of methotrexate in my body I was given Voraxaze.