TARGETED CHEMOTHERAPY, DRUG CRIZOTINIB (XALKORI)
CRIZOTINIB (XALKORI) is an orally available tyrosine kinase inhibitor. It is an example of a target chemotherapy drug. It targets a specific protein (tyrosine kinase) within cancer cells, inhibits it and stops cancer cells from growing.
CRIZOTINIB is generic with the brand name XALKORI
It is manufactured by Pfizer. CRIZOTINIB capsules received FDA approval in November 2013 for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive as detected by an FDA-approved test.
Can cause Drug-induced hepatotoxicity with fatal outcome
In the USA is averagely $15,000 for 60 200mg and 250mg capsules at $250 per capsule.
Chart showing price range in different pharmacies in the US
In Canada the price for CRIZOTINIB is averagely $187 for a 250 mg capsuleIn India CRIZOTINIB is sold by the name of Crizalk and it is cheaper than XALKORI.
Buy CRIZOTINIB online to spend less and save more. At Medicineinneed.org we offer CRIZOTINIB at the cheapest prices. We deliver all over the world so wherever you are just log into our site and order yours today and save a lot.
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CRIZOTINIB (XALKORI) Product Description
CRIZOTINIB is an orally available aminopyridine-based tyrosine kinase inhibitor. It is indicated for the treatment of patients with metastatic non-small cell lung carcinoma (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive.It comes in two different strengths 250 mg and 200mg.It is only available with a valid prescription from your doctor.Grapefruit and grapefruit juice may increase CRIZOTINIB blood concentrations increasing risk of side effects. Avoid the use of grapefruit products while taking Xalkori.Do not drive after taking CRIZOTINIB. This medicine may cause blurred vision and may impair your reflexes.CRIZOTINIB can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient’s body fluids.
CRIZOTINIB (XALKORI) PRESCRIBING INFORMATION
It’s different for different patients. Key is to follow your doctor’s directions.DOSAGE FORMS AND STRENGTHS
- 250 mg Crizotinib capsules hard gelatin capsule, pink opaque body and cap, with “Pfizer” on the cap and “CRZ 250” on the body.
- 200 mg Crizotinib capsules hard gelatin capsule, white opaque body and pink opaque cap, with “Pfizer” on the cap and “CRZ 200” on the body.
The recommended dose of CRIZOTINIB (XALKORI) is 250 mg orally, twice daily until disease progression or no longer tolerated by the patient. In severe renal impaired patients (creatinine cl<30 mL/min) not requiring dialysis, XALKORI recommended dose 250 mg orally, once daily. For treatment of non small cell lung carcinoma Swallow Xalkori capsules whole. Do not crush, dissolve or open capsules. Stick to your doctor’s prescription and do not share your medication.Take with or without food.
Before taking CRIZOTINIB (XALKORI)
Way the advantages and disadvantages with your doctor.Inform your doctor of any other medication you are taking (prescription and non prescription meds.) also supplements and vitamins.Inform your doctor if you are pregnant, plan to get pregnant, or are breastfeeding. You should not get pregnant while taking CRIZOTINIB. It is in pregnancy category D.Tell your doctor of any known allergies that you might have. Also tell him/her of any medical conditions you might have e.g. liver or kidney problems.
Take the missed dose as soon as you remember but not close to your next dose, if so skip the missed dose and resume your regular schedule. Make sure to inform you doctor about the missed dose.
CRIZOTINIB (XALKORI) Safety and storage
- Keep out of reach of children
- Discard if outdated and ask health care provider on how best to dispose off
- Store CRIZOTINIB in a cool and dry closed space, not in a bathroom. At room temperature
- Do not share your medication with someone else.
What are the CRIZOTINIB (XALKORI) Side effects?
The most common side effects of crizotinib include;
Vision disorders, nausea, diarrhea, vomiting, constipation, edema, elevated transaminases, and fatigue.
- Vision disorders – most commonly visual impairment, photopsia, blurred vision, or vitreous floaters.
- Hepatotoxicity-Drug induced with possible fatal outcome
- Elevation of Transaminases- alanine aminotransferase (ALT) and alkaline phosphate.
- Neuropathy- mostly sensory in nature
- Renal cysts.
- Decreased appetite
- Upper respiratory infection
- Severe, life-threatening, or fatal interstitial lung disease can occur in patients treated with XALKORI.
- QT interval prolongation can occur.
It is a Pregnancy category D medicine therefore contraindicated in pregnancy because it can harm the unborn child.
Your doctor will monitor you regularly while on this drug to check for side effects and progress.
CRIZOTINIB (XALKORI) Drug interactions
It has several drug interactions. Those contraindicated include:
The following use an alternative:
- fentanyl intranasal
- fentanyl iontophoretic transdermal system
- fentanyl transdermal
- fentanyl transmucosal
- irinotecan liposomal
- umeclidinium bromide/vilanterol inhaled
- vilanterol/fluticasone furoate inhaled
Frequently asked questions
What happens when I miss a dose?
Take the missed dose as soon as possible but not too close to your next dose in which case skip the missed dose and return to the routine schedule. Do not take a double dose. Inform your doctor about this.
What are the most common side effects of CRIZOTINIB?
Common side effects of Crizotinib include :
- Vision disorders.
- Upset stomach
Does CRIZOTINIB interact with other drugs?
Yes it does interact with quite a number of drugs. To be safe tell your doctor of any medications you are taking.
Are manufacture coupons available for CRIZOTINIB?
Crizotinib offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor’s office.There no current coupons for this drug.
When will my order ship?
Orders are shipped Monday through Friday, excluding legal holidays.
How do I track my order to know where it is in transit?
Every time you place an order, you’ll receive an email from us notifying you of its status. There no current coupons for this drug.
“While on Crizotinib I gained my weight back, got my strength back was able to eat again. Generally I have made progress while taking this drug.”
“I have been on this drug for ten months. No terrible side effects. My ct scans show my cancer to be nearly gone. My once large lymph nodes are no longer considered to be pathological”
“I have been on Crizotinib since August 2013. No severe side effects. Minimal nausea when taking without food. I also have some issues with swollen feet and legs. My last scans showed marked decrease in the size of lymph nodes and plural effusion”
“I’ve been on Crizotinib (Xalkori) for 8 months. This is the 5th and by far the easiest treatment I’ve been on since being diagnosed with Stage IV cancer 26 months ago.”
“After six months on this medication, I have shown “significant improvement” in both lungs, have no shortness of breath and much more energy.”
“I have experienced nausea and vomiting, visual disturbances; sometimes seeing dark images out of the corner of my eye and when going from a dark room to a lit one. I am pleased that xalkori has reduced the size of lymph nodes.”
“The side effects can be severe but the medication is working for me”
“I have been on CRIZOTINIB for 39 months for stage IV lung cancer. I have experienced a few side effects. I did have vision problems, some nausea and constipation at first. Now those are just about normal. The only problem I am having now is lymphedema of my legs but it is suppressing my cancer”